Ectopic liver and hepatocarcinogenesis

Hepatocarcinogenesis in liver cirrhosis: imaging diagnosis.

Hepatocellular carcinoma (HCC) frequently occurs in association with liver cirrhosis, as chronic liver disease is one of the most important factors in carcinogenesis. In addition to HCCs, recent reports of pathologic studies of resected specimens from cirrhotic liver describe associated small nodular lesions such as regenerative nodule, dysplastic nodule (adenomatous hyperplasia), and dysplasti...

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

BACKGROUND FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes under metabolic stress caused by starvation, hepatosteatosis, obesity and diabetes. Hepatic FGF21 elicits metabolic benefits by targeting adipocytes of the peripheral adipose tissue through the transmembrane FGFR1-...

The role of decorin in liver fibrogenesis and hepatocarcinogenesis

Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis

Inflammation is a major stimulus for carcinogenesis; however inflammation can also inhibit tumor growth and deplete malignant cells. The differences between cancer-promoting and cancer-inhibitory inflammation are not clear. We identified Interferon-γ as a major mediator of cancer-inhibitory inflammation that promotes anti-cancer immunity in the liver and sensitizes malignant hepatocytes for apo...

Laparoscopic Management of Gallbladder-Associated Ectopic Liver

Ectopic liver is a rare entity discussed infrequently in the surgical literature. Liver ectopia develops due to rests of liver parenchyma retained at various intraperitoneal or intrathoracic locations during migration of the liver proper during embryologic development. It is usually found during exploration for other diagnoses, commonly diseases of the biliary tree. We report a case in which a ...